- Foods with Function Claims
NEXT-Ⅱ®
NEXT-II® is a domestically produced, next-generation, undenatured type II collagen material that was developed exclusively by Ryusendo. Its patented manufacturing process preserves the three-dimensional structure of type II collagen, ensuring high purity and physiological activity. Clinical trials involving healthy Japanese subjects confirmed its effectiveness in improving joint mobility and flexibility, and enhancing comfort during daily activities. Safety testing also yielded favourable results. In addition to domestic GMP-compliant quality control, it meets U.S. self-affirmed GRAS and Halal certification standards. This highly reliable joint support ingredient is suitable for use in a wide range of products, from supplements to functional foods.
- Material name
- NEXT-Ⅱ®
- Common name
- Next Generation Undenatured Type Ⅱ Collagen
- Stanndard composition
- undenatured type Ⅱ collagen more than 10%
- Packing style unit
- 1kg,10kg
- Shelf life
- Three years when stored in tightly closed containers in a dark, cool, dry place. Limit exposure to air.
Ingredient information
Next Generation Undenatured Type Ⅱ Collagen「NEXT-Ⅱ® 」
～ Manufacturing in Japan × Japanese Clinical Evidence × “High Purity” Undenatured type Ⅱ collagen ～
～ Manufacturing in Japan × Japanese Clinical Evidence × “High Purity” Undenatured type Ⅱ collagen ～
What is next generation joint support material “NEXT-Ⅱ®”?
NEXT-Ⅱ®”,developed and selling by Ryusendo, is the next generation undenatured type Ⅱ collagen. By extracting and purifying type II collagen—the primary component of articular cartilage—without denaturing it (using a patented method), the collagen's unique three-dimensional structure is preserved. This enables support for joint function via immune tolerance (oral tolerance). Next-generation undenatured type II collagen® is a high-quality ingredient that pursues both functionality and safety, supporting the development of a wide range of products including supplements and foods with functional claims.
Clinical trial data involving healthy Japanese subjects
“NEXT-II®” has been confirmed in clinical trials involving healthy Japanese individuals to be effective in improving joint flexibility and mobility, reducing discomfort in the knees and lower back during daily activities, and enhancing smooth walking and stair climbing movements. Furthermore, safety studies conducted on Japanese subjects using NEXT-II® (at 10 times the recommended intake level) have confirmed no issues, establishing it as a material safe for long-term consumption. This enables its application in evidence-based Foods with Function Claims.
Domestic manufacturing with high-quality control
“NEXT-II®” is manufactured domestically. Under a GMP-compliant management system, we ensure stable quality and traceability. Japan's technological expertise enables a precise manufacturing process that preserves the three-dimensional structure of non-denatured Type II collagen, maintaining its superior physiological activity.
High-purity, high-content Type II collagen
“NEXT-Ⅱ®”achieves a undenatured type II collagen content of 10% or more. This high-purity formulation stands apart from typical collagen ingredients, delivering high functionality even at low doses (40mg/day). It is also compatible with a wide range of dosage forms, including tablets, capsules, and powdered drinks.
Compatible with global market
NEXT-II® holds Halal certification, enabling its expansion into diverse markets such as Asia and the Middle East. It is gaining attention as a next-generation ingredient offering both international credibility and market reach for OEM/ODM manufacturers, raw material trading companies, and health food brands worldwide.
Summary
“NEXT-Ⅱ®”is
●Functionality and safety demonstrated through clinical trials involving healthy Japanese subjects
●Domestic manufacturing with high-quality control
●High-content, high-purity undenatured Type II collagen
●Compatible with global market through Halal Certification
This is the “Next-Generation Uenatured Type II Collagen®” ingredient featuring these characteristics. In product development aimed at maintaining and supporting joint function, we can differentiate ourselves through solid evidence and quality.
●Functionality and safety demonstrated through clinical trials involving healthy Japanese subjects
●Domestic manufacturing with high-quality control
●High-content, high-purity undenatured Type II collagen
●Compatible with global market through Halal Certification
This is the “Next-Generation Uenatured Type II Collagen®” ingredient featuring these characteristics. In product development aimed at maintaining and supporting joint function, we can differentiate ourselves through solid evidence and quality.
Inquiry
For inquiries or consultations regarding raw materials, please feel free to contact us using the [Contact Form] below.
- RYUSENDO CO., LTD.
- 1-5-3 Nishi-ikebukuro,
Toshima-ku, Tokyo 171-0021,
Japan - TEL. 03-3985-8346
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